While it has been known that during the recombination-prone replication of enteroviruses results in truncated-genome "Defective Interfering Particles" (DIPs) our lab has recently investigated engineering truncated regions into the Poliovirus genome. These enterovirus Therapeutic Interfering Particles (eTIPs) are observed to outcompete WT-genomes when competing for replication resources in the same cell and have demonstrated therapeutic effects against RNA viruses in animal models.

The precise mechanism of interference is still under investigation, with studies into interferron induction and basic science behind eTIP/DIP replication in cell culture currently being done.