I am interested in antiviral defenses of mammals, such as the interferon response. I recently started exploring a model system based on Nodamura virus (NoV). While NoV infects insects, its RNA can replicate in a wide variety of hosts, including mammalian cells. The requirements for replication, detection of viral RNA by the host, and various host-pathogen interactions can be illuminated in this system.
I am also interested in host-virus interactions more generally. To this end, I am studying post-translational modifications induced in the cell upon poliovirus infection.
Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. Gitlin L, Benoit L, Song C, Cella M, Gilfillan S, Holtzman MJ, Colonna M. PLoS Pathog. 2010 Jan 22;6(1):e1000734.
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Gitlin L, Barchet W, Gilfillan S, Cella M, Beutler B, Flavell RA, Diamond MS, Colonna M. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8459-64. Epub 2006 May 19.
Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches. Gitlin L, Stone JK, Andino R. J Virol. 2005 Jan;79(2):1027-35.
Short interfering RNA confers intracellular antiviral immunity in human cells. Gitlin L, Karelsky S, Andino R. Nature. 2002 Jul 25;418(6896):430-4. Epub 2002 Jun 26.