Elizabeth Faul Goldstein
Elizabeth's primary interest is immunology and virology, especially the host-virus interactions that occur during infectious disease. In graduate school she investigated the triggering of the innate immune response to rabies virus, a negative-stranded RNA virus. Currently, she is working towards developing a protein interactome for coxsackievirus B3, a positive-stranded RNA virus, by affinity tag- mass spectrometry. The interactome will define previously unknown interactions that occur between host and viral proteins following infection.
Elizabeth is also interested in translation research, specifically vaccine development. Her past research included using a novel vaccine vector (attenuated rabies virus) to deliver HIV-1 proteins to the vaccinee and elicit an immune response. Currently, she is using known mutations in the polio virus polymerase to rationally engineer an attenuated polio virus that can be used in the polio eradication efforts.
(ALSO PUBLISHED AS Elizabeth J Faul)
- Wanjalla CN, Goldstein EF, Wirblich C, Schnell MJ. A role for granulocyte-macrophage colony-stimulating factor in the regulation of CD8(+) T cell responses to rabies virus. Virology. 2012. 426(2): 120-33.
- Wanjalla CN, Faul EJ, Gomme EA, Schnell MJ. Dendritic cells infected by recombinant rabies virus vaccine vector expressing HIV-1 Gag are immunogenic even in the presence of vector-specific immunity. Vaccine. 2010. 29(1): 130-40.
- Faul EJ, Wanjalla CN, Suthar MS, Gale M Jr., Wirblich C, Schnell MJ. Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling. PLOS Pathogens. 2010. 6(7).
- Gomme EA, Faul EJ, Flomenberg P, McGettigan JP, Schnell MJ. Characterization of a single-cycle rabies virus based vaccine vector. J Virology. 2010. 84(6): 2820-2831.
- Faul EJ, Lyles DS, Schnell MJ. The interferon response and viral evasion by members of the family Rhabdoviridae. Viruses. 2009. 1(3): 832-851.
- Faul EJ, Aye PP, Papaneri AB, Pahar B, McGettigan JP, Schiro F, Chervoneva I, Montefiori DC, Lackner AA, Schnell MJ. Rabies virus-based vaccines elicit neutralizing antibodies, poly-functional CD8+ T cell, and protect rhesus macaques from AIDS-like disease after SIVmac251 challenge. Vaccine. 2009. 28(2): 299-308.
- Snook AE, Li P, Stafford BJ, Faul EJ, Huang L, Birbe RC, Bombonati A, Schulz S, Schnell MJ, Eisenlohr LC, Waldman SA. Lineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease. Cancer Res. 2009. 69(8): 3537-44.